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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
03/07/2021 |
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Data da última atualização: |
31/08/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
VIANA, J. H. M.; PEREIRA, N. E. S.; FARIA, O. A. C.; DIAS, L. R. O.; OLIVEIRA, E. R.; FERNANDES, C. A. C.; SIQUEIRA, L. G. B. |
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Afiliação: |
JOAO HENRIQUE MOREIRA VIANA, Cenargen; NATHALIA ELLEN SOUSA PEREIRA, UNB; OTAVIO AUGUSTO COSTA FARIA, UNB; LUZIA RENATA OLIVEIRA DIAS, UNB; EDUARDO RAMOS OLIVEIRA, UNIFENAS; CARLOS ANTONIO CARVALHO FERNANDES, UNIFENAS; LUIZ GUSTAVO BRUNO SIQUEIRA, CNPGL. |
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Título: |
Active immunization against GnRH as an alternative therapeutic approach for the management of Bos indicus oocyte donors diagnosed with chronic cystic ovarian disease. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Theriogenology, v. 172, p. 133-141, 2021. |
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DOI: |
https://doi.org/10.1016/j.theriogenology.2021.06.014 |
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Idioma: |
Inglês |
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Conteúdo: |
The aim of this study was to evaluate the effect of active immunization against GnRH in Nelore (Bos indicus) cows repeatedly used as oocyte donors that developed chronic cystic ovarian disease (COD). In the first experiment, ovarian and uterine features were first compared between COD cows (n ¼ 15) and healthy cows (n ¼ 22, cycling control group) from the same breed and herd. Cows with COD had a greater number of large (P < 0.0001) and medium follicles (P < 0.01) but lesser small follicles (P < 0.05) than cycling controls. Mucometra was diagnosed in 73.3% of COD cows, but in none of the controls. No difference in average thickness of the endometrium was detected between groups; however, endometrial thickness and mucometra score were negatively correlated (R ¼ 0.73, P ¼ 0.0029) in COD cows. In the second experiment, COD cows were randomly allocated into two experimental groups, which received two 1.0 mL SC injections of either an anti-GnRH vaccine (COD immunized group, n ¼ 8) or saline (COD control group, n ¼ 7), given 28 days apart. Cows were examined weekly by transrectal ultrasonography during nine consecutive weeks after the first injection to evaluate the number and distribution of follicles among size classes, endometrial thickness, and presence of clinical mucometra. Vaccination against GnRH resulted in a progressive suppression of follicle growth and a reduction in the average size of the largest follicle, as well as in the number of large follicles (P < 0.01) in COD immunized cows compared with COD controls from week 7 onwards. Conversely, the number of small follicles in the COD immunized group increased after week 5 and was greater (P ¼ 0.0023) than controls on week 9. Endometrial thickness and mucometra score were not affected (P > 0.05) by immunization against GnRH. In the third experiment, the COD immunized cows with effective suppression of follicle growth four weeks after the 2nd injection (n ¼ 6) were submitted to three consecutive ovum pick-up (OPU) sessions (weeks 10, 11, and 12) for in vitro embryo production (IVEP). Cumulus-oocyte complexes (COC) collected from slaughterhouse ovaries were used as controls for IVEP. COD cows with produced 25.0 ± 3.8 COC per OPU session with no apparent detrimental effect of anti-GnRH vaccine on oocyte developmental potential in vitro, i.e., we observed similar cleavage rate (P ¼ 0.5914) and greater blastocyst rate (P ¼ 0.0177) in immunized cows compared with COC from slaughterhouse controls. Finally, in the fourth experiment wave emergence and follicular dynamics after follicle ablation were compared between COD immunized cows with effective suppression of follicle growth and a subset (n ¼ 6) of the cycling, control group. No follicles grew beyond 4 mm diameter after follicle ablation in the COD immunized group, whereas a normal follicular wave emergence occurred in cycling controls. Antral follicle count was similar between cycling controls and COD immunized groups at 24 h and 96 h post-follicle ablation (P > 0.05), but greater in cycling controls at 48 h and 72 h post-follicle ablation (P < 0.05). In summary, our results suggest that active immunization against GnRH is effective to induce the regression of follicular cysts as well as increase the number of small follicles growing on the ovaries, in oocyte donors diagnosed with chronic COD, with no apparent negative effect on oocyte developmental potential in vitro. MenosThe aim of this study was to evaluate the effect of active immunization against GnRH in Nelore (Bos indicus) cows repeatedly used as oocyte donors that developed chronic cystic ovarian disease (COD). In the first experiment, ovarian and uterine features were first compared between COD cows (n ¼ 15) and healthy cows (n ¼ 22, cycling control group) from the same breed and herd. Cows with COD had a greater number of large (P < 0.0001) and medium follicles (P < 0.01) but lesser small follicles (P < 0.05) than cycling controls. Mucometra was diagnosed in 73.3% of COD cows, but in none of the controls. No difference in average thickness of the endometrium was detected between groups; however, endometrial thickness and mucometra score were negatively correlated (R ¼ 0.73, P ¼ 0.0029) in COD cows. In the second experiment, COD cows were randomly allocated into two experimental groups, which received two 1.0 mL SC injections of either an anti-GnRH vaccine (COD immunized group, n ¼ 8) or saline (COD control group, n ¼ 7), given 28 days apart. Cows were examined weekly by transrectal ultrasonography during nine consecutive weeks after the first injection to evaluate the number and distribution of follicles among size classes, endometrial thickness, and presence of clinical mucometra. Vaccination against GnRH resulted in a progressive suppression of follicle growth and a reduction in the average size of the largest follicle, as well as in the number of large follicles (P < 0.01) in COD ... Mostrar Tudo |
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Palavras-Chave: |
Follicle growth suppression; GnRH vaccine; In vitro embryo production; Nelore breed. |
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Thesagro: |
Bovino; Doença Animal; Gado Nelore. |
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Categoria do assunto: |
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L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 04414naa a2200289 a 4500
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005 2021-08-31
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.theriogenology.2021.06.014$2DOI
100 1 $aVIANA, J. H. M.
245 $aActive immunization against GnRH as an alternative therapeutic approach for the management of Bos indicus oocyte donors diagnosed with chronic cystic ovarian disease.$h[electronic resource]
260 $c2021
520 $aThe aim of this study was to evaluate the effect of active immunization against GnRH in Nelore (Bos indicus) cows repeatedly used as oocyte donors that developed chronic cystic ovarian disease (COD). In the first experiment, ovarian and uterine features were first compared between COD cows (n ¼ 15) and healthy cows (n ¼ 22, cycling control group) from the same breed and herd. Cows with COD had a greater number of large (P < 0.0001) and medium follicles (P < 0.01) but lesser small follicles (P < 0.05) than cycling controls. Mucometra was diagnosed in 73.3% of COD cows, but in none of the controls. No difference in average thickness of the endometrium was detected between groups; however, endometrial thickness and mucometra score were negatively correlated (R ¼ 0.73, P ¼ 0.0029) in COD cows. In the second experiment, COD cows were randomly allocated into two experimental groups, which received two 1.0 mL SC injections of either an anti-GnRH vaccine (COD immunized group, n ¼ 8) or saline (COD control group, n ¼ 7), given 28 days apart. Cows were examined weekly by transrectal ultrasonography during nine consecutive weeks after the first injection to evaluate the number and distribution of follicles among size classes, endometrial thickness, and presence of clinical mucometra. Vaccination against GnRH resulted in a progressive suppression of follicle growth and a reduction in the average size of the largest follicle, as well as in the number of large follicles (P < 0.01) in COD immunized cows compared with COD controls from week 7 onwards. Conversely, the number of small follicles in the COD immunized group increased after week 5 and was greater (P ¼ 0.0023) than controls on week 9. Endometrial thickness and mucometra score were not affected (P > 0.05) by immunization against GnRH. In the third experiment, the COD immunized cows with effective suppression of follicle growth four weeks after the 2nd injection (n ¼ 6) were submitted to three consecutive ovum pick-up (OPU) sessions (weeks 10, 11, and 12) for in vitro embryo production (IVEP). Cumulus-oocyte complexes (COC) collected from slaughterhouse ovaries were used as controls for IVEP. COD cows with produced 25.0 ± 3.8 COC per OPU session with no apparent detrimental effect of anti-GnRH vaccine on oocyte developmental potential in vitro, i.e., we observed similar cleavage rate (P ¼ 0.5914) and greater blastocyst rate (P ¼ 0.0177) in immunized cows compared with COC from slaughterhouse controls. Finally, in the fourth experiment wave emergence and follicular dynamics after follicle ablation were compared between COD immunized cows with effective suppression of follicle growth and a subset (n ¼ 6) of the cycling, control group. No follicles grew beyond 4 mm diameter after follicle ablation in the COD immunized group, whereas a normal follicular wave emergence occurred in cycling controls. Antral follicle count was similar between cycling controls and COD immunized groups at 24 h and 96 h post-follicle ablation (P > 0.05), but greater in cycling controls at 48 h and 72 h post-follicle ablation (P < 0.05). In summary, our results suggest that active immunization against GnRH is effective to induce the regression of follicular cysts as well as increase the number of small follicles growing on the ovaries, in oocyte donors diagnosed with chronic COD, with no apparent negative effect on oocyte developmental potential in vitro.
650 $aBovino
650 $aDoença Animal
650 $aGado Nelore
653 $aFollicle growth suppression
653 $aGnRH vaccine
653 $aIn vitro embryo production
653 $aNelore breed
700 1 $aPEREIRA, N. E. S.
700 1 $aFARIA, O. A. C.
700 1 $aDIAS, L. R. O.
700 1 $aOLIVEIRA, E. R.
700 1 $aFERNANDES, C. A. C.
700 1 $aSIQUEIRA, L. G. B.
773 $tTheriogenology$gv. 172, p. 133-141, 2021.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 73 | |
| 1. |  | MIYAUCHI, C. A. C.; FERNANDES, C. A. C.; OLIVEIRA, E. R.; ALVES, B. F. L.; VIANA, J. H. M. Effect of follicular wave synchronization and absence of corpus luteum on coc recovery in gyr (Bos taurus indicus) cows. Reproduction, Fertility and Development, v. 22, n. 1, 2010. Edição dos proceedings do Annual Conference of the International Embryo, 2010, Cordoba.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 3. | | FERREIRA, A. M.; SA, W. F.; VIANA, J. H. M.; FERNANDES, C. A. C.; CAMARGO, L. S. A. Taxa de nao retorno ao cio em 60 dias e taxa de prenhez em bovinos. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Belo Horizonte, v. 49, n. 2, p. 261-267, 1997.| Biblioteca(s): Embrapa Gado de Leite. |
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| 5. | | VIANA, J. H. M.; PEREIRA, N. E. S.; FARIA, O. A. C.; DIAS, L. R. O.; OLIVEIRA, E. R.; FERNANDES, C. A. C.; SIQUEIRA, L. G. B. Active immunization against GnRH as an alternative therapeutic approach for the management of Bos indicus oocyte donors diagnosed with chronic cystic ovarian disease. Theriogenology, v. 172, p. 133-141, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia. |
|  |
| 6. | | VARAGO, F. C.; SILVA, L. P.; RIBEIRO, J. R.; FERNANDES, C. A. C.; CARVALHO, B. C. de; GIOSO, M. M.; GIMENEZ, M.; NEVES, J. P. Acrosome reaction induced by theophylline associated or not to heparin in bovine semen Animal Reproduction, v. 12, n. 3, 2015. Edição dos proceedings do 29º Annual Meeting of the Brazilian Embryo Technology Society, 2015, Gramado.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 7. | | VIANA, J. H. M.; CAMARGO, L. S. A.; FONSECA, J. F.; OLIVEIRA, A. P.; ARASHIRO, E. K. N.; FREITAS, C.; FERNANDES, C. A. C. Retrospective analysis of cumulus-oocyte complexyield in a gyr (Bos Taurus Indicus) herd undergoing trasvaginal ultrasound-guided fillicle aspiration. In: REPRODUCTION, FERTILITY AND DEVELOPMENT. 20. 2008, Anais. Colorado. Csiro, Academy of Science, 2008. 1 p.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 8. | | VIANA, J. H. M.; CAMARGO, L. S. H.; FONSECA, J. F. da; OLIVEIRA, A. P.; ARASCHIRO, E. K. N.; FREITAS, C.; FERNANDES, C. A. C. Retrospective analysis of cumulus-oocyte complex yield ina GYR (Bos Taurus indicus) herd undergoing transvaginal ultrasound-guided follicle aspiration. Reproduction, Fertility and Development, v. 20, n. 1, p. 189, 2008. Edição dos proceedings da Annual Conference or the International Embryo Transfer Society, Denver, Colorado, 2008.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 9. | | VIANA, J. H. M.; PALHÃO, M. P.; ARASHIRO, E. K. N.; FERREIRA, A. M.; FONSECA, J. F. da; FERNANDES, C. A. C. Pre-sincronização de vacas para coleta de complexos cumulus-oócito: resultados parciais. Acta Scientiae Veterinariae, Porto Alegre, v. 32, p. 187, 2004. Suplemento.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 10. | | GUIMARÃES, C. R. B.; OLIVEIRA, M. E.; ROSSI, J. R.; FERNANDES, C. A. C.; VIANA, J. H. M.; PALHAO, M. P. Corpus luteum blood flow evaluation on Day 21 to improve the management of embryo recipient herds. Theriogenology, v. 84, n. 2, p. 237-241, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 11. | | FERNANDES, C. A. C.; OLIVEIRA, E. R.; VASCONCELOS, T. D.; ALVES, B. F. L.; GIOSO, M. M.; VIANA, J. H. M.; OBA, E.; FIGUEIREDO, A. C. S. Bipartição de embriões bovinos em diferentes estádios de desenvolvimento. Acta Scientiae Veterinariae, v. 35, p. s1215, 2007. Supl. 3. Edição dos anais da 21ª Reunião Anual da Sociedade Brasileira de Tecnologia de Embriões, Salvador, 2007.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 12. | | VIANA, J. H. M.; CAMARGO, L. S. A.; SIQUEIRA, L. G. B.; SOUZA, E. D.; FREITAS, C.; FERNANDES, C. A. C. Characteristics of the superovulatory response in Gyr (Bos Indicus) cattle. Reproduction, Fertility and Development, v. 19, n. 1, p. 311-312, 2007. Edição dos proceedings do Annual Conference of the Internatinal Embryo Transfer Society, 2007, Kyoto.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 13. | | FERNANDES, C. A. C.; FIGUEIREDO, A. C. S.; OLIVEIRA, E. R.; VASCONCELOS, T. D.; ALVES, B. F. L.; GIOSO, M. M.; VIANA, J. H. M.; OBA, E. Estrus detection efficiency in embryo recipients synchronized with cloprostenol Acta Scientiae Veterinariae, v. 34, s493, 2006. Supl. 1. Edição dos resumos da 20ª Reunião Anual da Sociedade Brasileira de Tecnologia de Embriões, Araxá, 2006.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 14. | | SIQUEIRA, L. G. B.; VIANA, J. H. M.; SOUZA, E. D.; ARASHIRO, E. K. N.; CAMARGO, L. S. A.; FONSECA, J. F. da; FERNANDES, C. A. C. Eficiência na indução da luteólise em diferentes dias após a coleta de embriões em bovinos (resultados parciais). Acta Scientiae Veterinariae, v. 35, p. s1230, 2007. Supl. 3. Edição dos anais da 21ª Reunião Anual da Sociedade Brasileira de Tecnologia de Embriões, Salvador, 2007.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos; Embrapa Gado de Leite. |
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| 15. | | FIGUEIREDO, A. C. S.; FERNANDES, C. A. C.; NERI, H. L. H.; PEREIRA, G. H. S.; PEREIRA, J. R.; VIANA, J. H. M.; VIEIRA, M. R. Efficiency of in vivo embryo production using sorted semen in cattle. Animal Reproduction, v. 15, n. 3, p. 452, Jul./Sept. 2018. Proceedings of the 32nd Annual Meeting of the Brazilian Embryo Technology Society (SBTE); Florianópolis, SC, Brazil, August 16th to 18th, 2018. Abstracts.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 16. | | VIANA, J. H. M.; VARGAS, M. S. B.; SIQUEIRA, L. G. B.; CAMARGO, L. S. de A.; FIGUEIREDO, A. C. S.; FERNANDES, C. A. C.; PALHÃO, M. P. Efficacy of induction of luteolysis in superovulated cows is dependent on time of prostaglandin F2alpha analog treatment: effects on plasma progesterone and luteinizing hormone profiles. Theriogenology, v. 86, n. 4, p. 934-939, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia. |
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| 17. | | FERNANDES, C. A. C.; RIBEIRO, J. A.; PALHÃO, M. P.; FIGUEIREDO, A. C. S.; VIANA, J. H. M.; COSTA, D. S.; ARASHIRO, E. K. N. Effect of season and weight gain on pregnancy rates of embryo recipients raised under pasture conditions. In: ANNUAL CONFERENCE OF THE INTERNATIONAL EMBRYO TRANSFER SOCIETY, 2013, Hannover. Proceedings... Hannover: [s.n.], 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 18. | | PATROCÍNIOS. T. A.; FERNANDES, C. A. C.; AMORIM, L. S.; RIBEIRO. J. R.; MACEDO, G. C.; SILVA, A. D.; VIANA, J. H. M.; CAMARGO, L. S. de A. Effect of reservatrol analogue on development of in vitro-fertilized bovine embryos. Reproduction, Fertility and Development, v. 29, n. 1, p. 183, 2017. Edição dos proceedings da Annual Conference of the International Embryo Technology Society, Austin, 2017.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 19. | | MOURA, R. M. de; MARTINS, L. P.; SIQUEIRA, L. G. B.; FERNANDES, C. A. C.; MARTINS, C. F.; FIGUEIREDO, R. A.; VIANA, J. H. M. Effect of the route of administration of recombinant human FSH on ovarian superestimulatory response in calves. Animal Reproduction, v. 19, n. 2, 2022. e22084. Proceedings of the 35rd Annual Meeting of the Brazilian Embryo Technology Society (SBTE); Foz do Iguaçu, August 2022. Abstracts.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Cerrados; Embrapa Recursos Genéticos e Biotecnologia. |
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| 20. | | MOURA, R. M. de; MARTINS, L. P.; SIQUEIRA, L. G. B.; FERNANDES, C. A. C.; MARTINS, C. F.; FIGUEIREDO, R. A.; VIANA, J. H. M. Effect of the route of administration of recombinant human FSH on ovarian superestimulatory response in calves. Animal Reproduction, v. 19, n. 2, e22084, 2022. Edição dos abstracts da Annual Meeting of the Brazilian Embryo Technology Society, 35., Foz do Iguaçu, 2022.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 73 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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